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Calindol hydrochloride
CAS No. 729610-18-8
Calindol hydrochloride( —— )
Catalog No. M15792 CAS No. 729610-18-8
Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCalindol hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCalindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM.
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DescriptionCalindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+); activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+); produces concentration-dependent hyperpolarizations of vascular myocytes from rat isolated mesenteric and porcine coronary arteries.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetCaSR
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RecptorCaSR
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Research Area——
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Indication——
Chemical Information
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CAS Number729610-18-8
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Formula Weight336.863
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Molecular FormulaC21H21ClN2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (296.86 mM)
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SMILESCC(C1=CC=CC2=CC=CC=C21)NCC3=CC4=CC=CC=C4N3.Cl
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Chemical NameN-[(1R)-1-(1-naphthalenyl)ethyl]-1H-indole-2-methanamine, monohydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kessler A, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9.
2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.
3. Ray K, et al. J Biol Chem. 2005 Nov 4;280(44):37013-20.
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